{"id":6793,"date":"2023-11-12T19:02:42","date_gmt":"2023-11-12T10:02:42","guid":{"rendered":"https:\/\/chirosonomanma.com\/info\/?p=6793"},"modified":"2025-12-06T11:49:24","modified_gmt":"2025-12-06T02:49:24","slug":"post-1124","status":"publish","type":"post","link":"https:\/\/chirosonomanma.com\/info\/post-1124\/","title":{"rendered":"\u6295\u85ac\u6cbb\u7642\u6642\u306e\u3046\u3064\u75c5\u306e\u65e9\u671f\u5bdb\u89e3\u306e\u4e88\u6e2c\u56e0\u5b50"},"content":{"rendered":"\n<p>\u304a\u85ac\u306b\u3088\u308b\u85ac\u306b\u3088\u308b\u3046\u3064\u75c5\u306e\u6cbb\u7642\u3092\u8003\u3048\u3066\u3044\u308b\u65b9\u3084\u3001 \u73fe\u5728\u884c\u3063\u3066\u3044\u308b\u65b9\u304c\u305d\u306e\u6cbb\u7642\u6cd5\u306b\u3088\u3063\u3066\u65e9\u671f\u306b\u56de\u5fa9\u3057\u3066\u3044\u308b\u304b\u3069\u3046\u304b\u304c\u3001\u3042\u308b\u7a0b\u5ea6\u5206\u304b\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u304d\u305f\u3088\u3046\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u7814\u7a76\u306b\u3088\u308b\u3068\u8840\u6db2\u691c\u67fb\u306b\u3088\u3063\u3066\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3068\u547c\u3070\u308c\u308b\u3001\u7d30\u80de\u304b\u3089\u5206\u6ccc\u3055\u308c\u308b\u4f4e\u5206\u5b50\u30bf\u30f3\u30d1\u30af\u8cea\uff08\u751f\u7406\u6d3b\u6027\u7269\u8cea\u306e\u7dcf\u79f0\uff09\u306e\u5e7e\u3064\u304b\u306e\u7a2e\u985e\u306e\u91cf\u306b\u3088\u3063\u3066\u65e9\u3044\u6bb5\u968e\u3067\u3046\u3064\u75c5\u304c\u826f\u304f\u306a\u308b\u304b\uff1f\u3082\u3057\u304f\u306f\u305d\u3046\u3067\u306a\u3044\u306e\u304b\u304c\u3042\u308b\u7a0b\u5ea6\u5224\u65ad\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u304d\u305f\u307f\u305f\u3044\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u7814\u7a76\u306f2022\u5e7412\u6708\u306b\u51fa\u3055\u308c\u305f\u7814\u7a76\u306a\u306e\u3067\u3001\u3053\u306e\u30d6\u30ed\u30b0\u3092\u66f8\u304f\u4e00\u5e74\u524d\u306e\u3042\u306e\u7814\u7a76\u3067\u3059\u3002\u77e5\u3063\u3066\u308b\u65b9\u3082\u591a\u3044\u304b\u3082\u3057\u308c\u306a\u3044\u3067\u3059\u3051\u3069\u3001\u77e5\u3089\u306a\u3044\u65b9\u3001\u305c\u3072\u53c2\u8003\u306b\u3057\u3066\u307f\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">SSRI\u3068NaSSA\u304c<strong>GM-CSF<\/strong>\u3068<strong>TNF-\u03b1<\/strong>\u3068<strong>IL-2<\/strong>\u3067\u5224\u65ad\u3067\u304d\u305d\u3046<\/h2>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u304a\u85ac\u306b\u3088\u308b\u3001\u3046\u3064\u75c5\u306e\u65e9\u671f\u5bdb\u89e3\u306e\u4e88\u6e2c\u56e0\u5b50: <\/li>\n\n\n\n<li>\u6297\u3046\u3064\u85ac\u306e\u6cbb\u7642\u53cd\u5fdc\u306f\u60a3\u8005\u3054\u3068\u306b\u7570\u306a\u308a\u3001\u6cbb\u7642\u524d\u306b\u4e88\u6e2c\u3059\u308b\u3053\u3068\u306f\u56f0\u96e3\u3067\u3042\u308b\u3002\u672c\u6587\u3067\u306f\u3001SSRI\u3068\u30df\u30eb\u30bf\u30b6\u30d4\u30f3\uff08<a href=\"https:\/\/www.bing.com\/search?q=%E6%8A%97%E3%81%86%E3%81%A4%E8%96%AC%23%E3%83%8E%E3%83%AB%E3%82%A2%E3%83%89%E3%83%AC%E3%83%8A%E3%83%AA%E3%83%B3%E4%BD%9C%E5%8B%95%E6%80%A7%E3%83%BB%E7%89%B9%E7%95%B0%E7%9A%84%E3%82%BB%E3%83%AD%E3%83%88%E3%83%8B%E3%83%B3%E4%BD%9C%E5%8B%95%E6%80%A7%E6%8A%97%E3%81%86%E3%81%A4%E8%96%AC(NaSSA)%20wikipedia&amp;form=WIKIRE&amp;PC=U531\">\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u4f5c\u52d5\u6027\u30fb\u7279\u7570\u7684\u30bb\u30ed\u30c8\u30cb\u30f3\u4f5c\u52d5\u6027\u6297\u3046\u3064\u85ac<\/a>\u00a0(NaSSA)\uff09\u306e\u6cbb\u7642\u53cd\u5fdc\u3068\u76f8\u95a2\u3059\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08\u7d30\u80de\u304b\u3089\u5206\u6ccc\u3055\u308c\u308b\u4f4e\u5206\u5b50\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u751f\u7406\u6d3b\u6027\u7269\u8cea\u306e\u7dcf\u79f0\uff09\u306e\u5206\u6790\u3092\u884c\u3063\u305f\u3002<\/li>\n\n\n\n<li>\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u5206\u6790\u65b9\u6cd5: \u6297\u3046\u3064\u85ac\u6cbb\u7642\u524d\u306e\u60a3\u800595\u4f8b\u3092\u5bfe\u8c61\u306b\u3001\u9175\u7d20\u7d50\u5408\u514d\u75ab\u5438\u7740\u6e2c\u5b9a\u6cd5\u3092\u7528\u3044\u3066<br><strong>TNF-\u03b1<\/strong>\uff08\u4e3b\u306b\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u3088\u308a\u7523\u751f\u3055\u308c\u3066\u304a\u308a\u3001\u56fa\u5f62\u304c\u3093\u306b\u5bfe\u3057\u3066\u51fa\u8840\u6027\u306e\u58ca\u6b7b\u3092\u751f\u3058\u3055\u305b\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff09<br><strong>IL-1\u03b2<\/strong>\uff08\u708e\u75c7 \u53cd\u5fdc\u306e\u91cd\u8981\u306a\u5a92\u4ecb\u56e0\u5b50\u3067\u3042\u308a\u3001\u7d30\u80de\u5897\u6b96\u3001\u00a0\u7d30\u80de\u5206\u5316 \u3001 \u30a2\u30dd\u30c8\u30fc\u30b7\u30b9 \u3092\u542b\u3080\u3055\u307e\u3056\u307e\u306a\u6d3b\u6027\u306b\u95a2\u4e0e\uff09<br><strong>IL-2<\/strong>\uff08\u672a\u5206\u5316\u306aT\u7d30\u80de(\u30ca\u30a4\u30fc\u30d6T\u7d30\u80de)\u53ca\u3073\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u03b3\u3084IL-12\u306e\u523a\u6fc0\u3092\u53d7\u3051\u3066\u30ca\u30a4\u30fc\u30d6T\u7d30\u80de\u304b\u3089\u5206\u5316\u3057\u305f1\u578b\u30d8\u30eb\u30d1\u30fcT\u7d30\u80de\u306b\u3088\u3063\u3066\u7523\u751f\u3055\u308c\u3001Th1\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3068\u547c\u3070\u308c\u308b\u30b0\u30eb\u30fc\u30d7\u306b\u5206\u985e\u3055\u308c\u308b\u3002IL-2\u306f\u7d30\u80de\u6027\u514d\u75ab\u306b\u95a2\u4e0e\uff09<br><strong>IL-4<\/strong>\uff08\u9020\u8840\u306a\u3069\u306b\u95a2\u4e0e\u3059\u308b\u30d8\u30de\u30c8\u30dd\u30a8\u30c1\u30f3\u30d5\u30a1\u30df\u30ea\u30fc\u3068\u3044\u3046\u30b5\u30d6\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u5206\u985e\u3055\u308c\u308b\u3002IL-4\u306f129\u500b\u306e\u30a2\u30df\u30ce\u9178\u304b\u3089\u69cb\u6210\u3055\u308c\u308b\u53ef\u6eb6\u6027\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308a\u3001\u6d3b\u6027\u5316CD4<sup>+<\/sup>\u00a0T\u7d30\u80de\u3092\u306f\u3058\u3081\u3001\u30de\u30b9\u30c8\u7d30\u80de\u3001NKT\u7d30\u80de\u306a\u3069\u306b\u3088\u3063\u3066\u7523\u751f\uff09<br><strong>IL-6<\/strong>\uff08T\u7d30\u80de\u3084\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u7b49\u306e\u7d30\u80de\u306b\u3088\u308a\u7523\u751f\u3055\u308c\u308b\u30ec\u30af\u30c1\u30f3\u3067\u3042\u308a\u3001\u6db2\u6027\u514d\u75ab\u3092\u5236\u5fa1\u3059\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u4e00\u3064\uff09<br><strong>IL-8<\/strong>\uff08\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3001\u4e0a\u76ae\u7d30\u80de\u3001\u6c17\u9053\u5e73\u6ed1\u7b4b\u7d30\u80de\u304a\u3088\u3073\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u304c\u7523\u751f\u3059\u308b\u203b\u30b1\u30e2\u30ab\u30a4\u30f3\u3067\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3\u306e1\u3064\uff09<br><strong>GM-CSF<\/strong>\uff08\u9846\u7c92\u7403\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u30b3\u30ed\u30cb\u30fc\u523a\u6fc0\u56e0\u5b50\uff08granulocyte-macrophage colony-stimulating factor\uff1b<strong>GM-CSF<\/strong>\uff09\u307e\u305f\u306f<strong>\u30b3\u30ed\u30cb\u30fc\u523a\u6fc0\u56e0\u5b502<\/strong>\uff08colony stimulating factor 2\uff1b<strong>CSF2<\/strong>\uff09\u306f\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3001T\u7d30\u80de\u3001\u80a5\u6e80\u7d30\u80de\u3001\u30ca\u30c1\u30e5\u30e9\u30eb\u30ad\u30e9\u30fc\u7d30\u80de\u3001\u5185\u76ae\u7d30\u80de\u3001\u7dda\u7dad\u82bd\u7d30\u80de\u306a\u3069\u304b\u3089\u5206\u6ccc\u3055\u308c\u308b\u5358\u91cf\u4f53\u306e\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308a\u3001\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3068\u3057\u3066\u6a5f\u80fd\uff09<br><br>\u203bG\u30bf\u30f3\u30d1\u30af\u8cea\u5171\u5f79\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u3066\u305d\u306e\u4f5c\u7528\u3092\u767a\u73fe\u3059\u308b\u5869\u57fa\u6027\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308a\u3001\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u4e00\u7fa4\u3067\u3042\u308b\u3002\u767d\u8840\u7403\u306a\u3069\u306e\u904a\u8d70\u3092\u5f15\u304d\u8d77\u3053\u3057\u708e\u75c7\u306e\u5f62\u6210\u306b\u95a2\u4e0e\u3059<br><br>\u306e\u5206\u6790\u3092\u884c\u3063\u305f\u3002\u3046\u3064\u75c7\u72b6\u306e\u8a55\u4fa1\u306f\u3001\u30cf\u30df\u30eb\u30c8\u30f3\u3046\u3064\u75c5\u8a55\u4fa1\u5c3a\u5ea6\u3092\u7528\u3044\u30664\u9031\u9593\u8abf\u67fb\u3057\u305f\u3002<\/li>\n\n\n\n<li><strong>\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3068\u5bdb\u89e3\u7387\u306e\u95a2\u4fc2<\/strong>: <span class=\"swl-marker mark_blue\">SSRI\u6cbb\u7642\u7fa4\u3067\u306f\u3001\u5bdb\u89e3\u8005\u306b\u304a\u3044\u3066\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306e<strong>GM-CSF<\/strong>\u30ec\u30d9\u30eb\u304c\u975e\u5bdb\u89e3\u8005\u3088\u308a\u3082\u6709\u610f\u306b\u9ad8\u304b\u3063\u305f<\/span>\u3002<\/li>\n\n\n\n<li>\u30df\u30eb\u30bf\u30b6\u30d4\u30f3\u6cbb\u7642\u7fa4\u3067\u306f\u3001<span class=\"swl-marker mark_blue\">\u5bdb\u89e3\u8005\u306b\u304a\u3044\u3066\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306e<strong>TNF-\u03b1<\/strong>\u30ec\u30d9\u30eb\u304c\u975e\u5bdb\u89e3\u8005\u3088\u308a\u3082\u6709\u610f\u306b\u9ad8\u304f\u3001<strong>IL-2<\/strong>\u30ec\u30d9\u30eb\u306f\u6709\u610f\u306b\u4f4e\u304b\u3063\u305f\u3002<\/span><\/li>\n\n\n\n<li><strong>\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u30ab\u30c3\u30c8\u30aa\u30d5\u5024<\/strong>: \u30df\u30eb\u30bf\u30b6\u30d4\u30f3\u6cbb\u7642\u7fa4\u3067\u306f\u3001<strong>TNF-\u03b1<\/strong>\uff0810.035 pg\/mL\uff09\u304a\u3088\u3073<strong>IL-2<\/strong>\uff081.170 pg\/mL\uff09\u306e\u30ab\u30c3\u30c8\u30aa\u30d5\u5024\u304c\u5bdb\u89e3\u7387\u3092\u4e88\u6e2c\u3059\u308b\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u305f\u3002SSRI\u6cbb\u7642\u7fa4\u3067\u306f\u3001<strong>GM-CSF<\/strong>\uff080.205 pg\/mL\uff09\u3092\u30ab\u30c3\u30c8\u30aa\u30d5\u5024\u3068\u3057\u3066\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u5bdb\u89e3\u7387\u304c\u7d042\u500d\u306b\u5897\u52a0\u3059\u308b\u3053\u3068\u304c\u63a8\u5b9a\u3055\u308c\u305f\u3002<\/li>\n<\/ul>\n<cite><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35193470\/\">Pre-treatment plasma cytokine levels as potential predictors of short-term remission of depression &#8211; PubMed (nih.gov)<\/a><\/cite><\/blockquote>\n\n\n\n<p>\u79c1\u306f\u30ab\u30a4\u30ed\u30d7\u30e9\u30af\u30bf\u30fc\u306a\u306e\u3067\u751f\u7406\u5b66\u306e\u5c02\u9580\u3067\u306f\u306a\u3044\u3057\u3001\u85ac\u7406\u5b66\u3082\u5c02\u9580\u3067\u306f\u306a\u3044\u3093\u3067\u3059\u3051\u308c\u3069\u3082\u3001\u60a3\u8005\u3055\u3093\u3054\u81ea\u8eab\u304c\u5224\u65ad\u3059\u308b\u306b\u3042\u305f\u3063\u3066\u3001\u3053\u308c\u304c\u30d9\u30b9\u30c8\u306a\u65b9\u6cd5\u3067\u306f\u306a\u3044\u304b\u3082\u3057\u308c\u306a\u3044\u3067\u3059\u3051\u308c\u3069\u3082\u3001\u73fe\u72b6\u306e\u30b1\u30a2\u306b\u304a\u3044\u3066\u6709\u52b9\u306a\u5224\u65ad\u6750\u6599\u306b\u306a\u308b\u3093\u3058\u3083\u306a\u3044\u304b\u306a\u3068\u601d\u3063\u3066\u4eca\u56de\u30d6\u30ed\u30b0\u306b\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u79c1\u3082\u52c9\u5f37\u3057\u306a\u304c\u3089\u30d6\u30ed\u30b0\u3092\u66f8\u3044\u3066\u308b\u3093\u3067\u3059\u3051\u3069\u3082\u5c11\u3057\u3067\u3082\u3046\u3064\u75c5\u306e\u60a3\u8005\u3055\u3093\u306e\u304a\u529b\u306b\u306a\u308c\u308c\u3070\u4f55\u3088\u308a\u3067\u3059\u3002\u3054\u53c2\u8003\u304f\u3060\u3055\u3044\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u85ac\u306b\u3088\u308b\u3046\u3064\u75c5\u306f\u4e00\u822c\u7684\u3067\u3059\u304c\u3001\u305d\u306e\u4e2d\u3067\u3082a\u6cbb\u308a\u304c\u65e9\u3044\u4eba\u306e\u8840\u6db2\u691c\u67fb\u306e\u50be\u5411\u3092\u304a\u4f1d\u3048\u3057\u307e\u3059\u3002<\/p>\n","protected":false},"author":2,"featured_media":7107,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"swell_btn_cv_data":"","footnotes":"","_wp_rev_ctl_limit":""},"categories":[373],"tags":[349,364],"class_list":["post-6793","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-mental-illness","tag-ssri-snri","tag-dipression"],"_links":{"self":[{"href":"https:\/\/chirosonomanma.com\/info\/wp-json\/wp\/v2\/posts\/6793","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/chirosonomanma.com\/info\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/chirosonomanma.com\/info\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/chirosonomanma.com\/info\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/chirosonomanma.com\/info\/wp-json\/wp\/v2\/comments?post=6793"}],"version-history":[{"count":4,"href":"https:\/\/chirosonomanma.com\/info\/wp-json\/wp\/v2\/posts\/6793\/revisions"}],"predecessor-version":[{"id":7108,"href":"https:\/\/chirosonomanma.com\/info\/wp-json\/wp\/v2\/posts\/6793\/revisions\/7108"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/chirosonomanma.com\/info\/wp-json\/wp\/v2\/media\/7107"}],"wp:attachment":[{"href":"https:\/\/chirosonomanma.com\/info\/wp-json\/wp\/v2\/media?parent=6793"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/chirosonomanma.com\/info\/wp-json\/wp\/v2\/categories?post=6793"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/chirosonomanma.com\/info\/wp-json\/wp\/v2\/tags?post=6793"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}