{"id":3530,"date":"2020-09-25T16:02:05","date_gmt":"2020-09-25T07:02:05","guid":{"rendered":"https:\/\/info.chirosonomanma.com\/?p=3530"},"modified":"2025-10-25T15:27:56","modified_gmt":"2025-10-25T06:27:56","slug":"post-3530","status":"publish","type":"post","link":"https:\/\/chirosonomanma.com\/info\/post-3530\/","title":{"rendered":"\u304a\u9152\u3092\u98f2\u3080\u3068\u7b4b\u8089\u304c\u786c\u304f\u306a\u308b"},"content":{"rendered":"\n

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2017\u5e74\u306e\u8ad6\u6587\u3000Simon L, Jolley SE, Molina PE. Alcoholic Myopathy: Pathophysiologic Mechanisms and Clinical Implications. Alcohol Res. 2017;38(2):207-217. PMID: 28988574; PMCID: PMC5513686.\u3000\u3092\u53c2\u8003\u306b\u66f8\u3044\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

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\u30a2\u30eb\u30b3\u30fc\u30eb\u4f7f\u7528\u969c\u5bb3\uff08Alcohol use disorder\u3001AUD\uff09\uff1d\u30a2\u30eb\u30b3\u30fc\u30eb\u4f9d\u5b58\u75c7\u306e\u4eba\u3067\u3001\u5148\u305a\u76ee\u7acb\u3064\u6804\u990a\u969c\u5bb3\u306f\u8449\u9178\u3001\u30c1\u30a2\u30df\u30f3\uff08\u30d3\u30bf\u30df\u30f3B1\uff09\u3001\u30d3\u30bf\u30df\u30f3B6\u3001\u4e9c\u925b\u3001\u9244\u3002\uff08Halsted 2004<\/a>\uff09\u3002<\/p>\n\n\n\n

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\n

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\u6162\u6027\u7684\u306a\u30a2\u30eb\u30b3\u30fc\u30eb\u306e\u5927\u91cf\u6d88\u8cbb\u306f\u9aa8\u683c\u7b4b\u306e\u708e\u75c7\u306b\u3064\u306a\u304c\u308a<\/span>\u3001\u30c8\u30e9\u30f3\u30b9\u30d5\u30a9\u30fc\u30df\u30f3\u30b0\u5897\u6b96\u56e0\u5b50\u03b2\uff08TGF-\u03b2\uff09\u306a\u3069\u306e\u7dda\u7dad\u5316\u4fc3\u9032\u56e0\u5b50\u306e\u767a\u73fe\u3092\u4fc3\u9032\u3057<\/span>\u3001Smad\uff08P-Smad\uff09\u306a\u3069\u306e\u8ee2\u5199\u56e0\u5b50\u306e\u767a\u73fe\u304a\u3088\u3073\u6d3b\u6027\u5316\uff08\u30ea\u30f3\u9178\u5316\uff09\u306e\u5897\u52a0\u3092\u523a\u6fc0\u3057\u307e\u3059\uff09\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a4\u30ca\u30fc\u30bc\uff08MMP\uff09\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u304c\u5909\u5316\u3057\u3001\u9aa8\u683c\u7b4b\u306e\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\uff08ECM\uff09\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u6c88\u7740\u304c\u5897\u52a0<\/span>\u3057\u307e\u3059\u3002<\/p>\n<\/div><\/div>\n\n\n\n

\u7c21\u5358\u306a\u89e3\u8aac\uff1a\u7dda\u7dad\u5316\u3068\u306f\u7b4b\u8089\u3084\u7b4b\u819c\u7d44\u7e54\uff08\u30d5\u30a1\u30b7\u30a2\uff09\u304c\u786c\u304f\u306a\u3063\u3066\u767d\u304f\u306a\u308b\u3053\u3068\u3067\u3059\u3002\u4e00\u65e6\u7dda\u7dad\u5316\u3057\u3066\u3057\u307e\u3063\u305f\u7b4b\u7d30\u80de\u306f\u5143\u306b\u306f\u3082\u3069\u308a\u307e\u305b\u3093\u3002\u3053\u308c\u304c\u8d77\u304d\u308b\u3068\u30a4\u30ef\u30e6\u30eb\u7b4b\u8089\u304c\u786c\u304f\u306a\u308b\u308f\u3051\u3067\u3059\u304c\uff08\u4f38\u3073\u306a\u304f\u306a\u308b\uff09\u6162\u6027\u306e\u5927\u91cf\u98f2\u9152\u3067\u306f\u8d77\u304d\u3066\u3044\u308b\u3053\u3068\u304c\u4e88\u6e2c\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n

\"\"\u30c9\u30af\u30bf\u30fc<\/span><\/div>
\n

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\u904b\u52d5\u80fd\u529b\u306b\u5bfe\u3059\u308b\u30a2\u30eb\u30b3\u30fc\u30eb\u6d88\u8cbb\u3068\u77db\u76fe\u3059\u308b\u7d50\u679c\u3082\u51fa\u3066\u3044\u308b<\/h4>\n\n\n\n

\u4f4e\u7528\u91cf\u306e\u30a2\u30eb\u30b3\u30fc\u30eb\u3078\u306e\u66b4\u9732<\/span>\u306f\u3001\u30b5\u30a4\u30af\u30eb\u30de\u30b7\u30f3\u307e\u305f\u306f\u30c8\u30ec\u30c3\u30c9\u30df\u30eb\u8a66\u9a13\u3092\u53d7\u3051\u3066\u3044\u308b\u5065\u5eb7\u306a\u53c2\u52a0\u8005\u306e\u30d4\u30fc\u30af\u904b\u52d5\u80fd\u529b\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u305b\u3093\u3067\u3057\u305f<\/span>\uff08Bond et <\/a>al\u30021984<\/a> ; Houmard et al\u30021987<\/a>\uff09\u3002<\/p>\n\n\n\n

\u540c\u69d8\u306b\u3001\u30c0\u30a4\u30ca\u30e2\u30e1\u30c8\u30ea\u30fc\u306b\u3088\u3063\u3066\u6e2c\u5b9a\u3055\u308c\u305f\u30d4\u30fc\u30af\u5f37\u5ea6\u306e\u4f4e\u4e0b\u306f\u3001\u4e2d\u7a0b\u5ea6\u306e\u30a2\u30eb\u30b3\u30fc\u30eb\u6d88\u8cbb\u3067\u660e\u3089\u304b\u3067\u3057\u305f\u304c\u3001\u4f4e\u30a2\u30eb\u30b3\u30fc\u30eb\u6d88\u8cbb\u3092\u5831\u544a\u3057\u305f\u500b\u4eba\u3067\u306f\u660e\u3089\u304b\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3068\u306e\u3053\u3068\u3002\u307b\u3069\u307b\u3069\uff081\u65e51\u5408\u307e\u3067\uff1d\u7f36\u30d3\u30fc\u30eb350\u4e00\u672c\uff09\u306a\u3089\u554f\u984c\u306a\u3044\u306e\u304b\u3082<\/span>\u3067\u3059\u306d\u3002<\/p>\n\n\n\n

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\"\u30b9\u30c8\u30c3\u30d7\u3092\u793a\u3059\u5973\u6027\u306e\u30a4\u30e1\u30fc\u30b8\"
\u7b4b\u8089\u306e\u305f\u3081\u306b\u304a\u9152\u3092\u98f2\u307e\u306a\u3044\u3067\uff01<\/figcaption><\/figure>\n\n\n\n

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\u3053\u306e\u5f71\u97ff\u306f\u708e\u75c7\u53cd\u5fdc\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u969c\u5bb3\u3001\u7b4b\u8089\u518d\u751f\u969c\u5bb3\u3001\u306a\u3089\u3073\u306b\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u304a\u3088\u3073\u30de\u30a4\u30af\u30edRNA\uff08miRNA\uff09\u95a2\u9023\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u542b\u307e\u308c\u308b\u3002\u85ac\u7269\u3067\u3059\u304b\u3089\u306a\u3042\u3002<\/p>\n\n\n\n

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\u305d\u3057\u3066\u3001\u7981\u9152\u3057\u3066\u904b\u52d5\u3000<\/h3>\n\n\n\n

\u3084\u3063\u3071\u308a\u904b\u52d5\u3067\u3059\u3002<\/p>\n\n\n\n

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\u8eab\u4f53\u6d3b\u52d5\u4ecb\u5165\u3001\u4e3b\u306b\u6709\u9178\u7d20\u904b\u52d5\u304a\u3088\u3073\/\u307e\u305f\u306f\u30ec\u30b8\u30b9\u30bf\u30f3\u30b9\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u6d3b\u52d5\u306e\u4f7f\u7528\u306f\u3001\u30a2\u30eb\u4e2d\u60a3\u8005\u306e\u904b\u52d5\u80fd\u529b\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08Brown et <\/a>al\u30022014<\/a> ; Capodaglio et al\u30022003<\/a>\uff09\u3002<\/p>\n\n\n\n

\u4ee5\u524d\u306e\u904b\u52d5\u306e\u7121\u4f5c\u70ba\u5316\u6bd4\u8f03\u8a66\u9a13\u306f\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u95a2\u9023\u30df\u30aa\u30d1\u30b7\u30fc\u306e\u60a3\u8005\u306b\u9650\u5b9a\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u4f7f\u7528\u969c\u5bb3\u60a3\u8005\uff08\u30a2\u30eb\u4e2d\uff09\u304c\u6a19\u6e96\u5316\u3055\u308c\u305f\u904b\u52d5\u4ecb\u5165\u3092\u53d7\u3051\u308c\u3070\u3001\u5bfe\u7167\u88ab\u9a13\u8005\u3068\u6bd4\u8f03\u3057\u3066\u6700\u5927\u9178\u7d20\u6d88\u8cbb\u91cf\u3068\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u5fc3\u62cd\u6570\u306b\u6709\u610f\u306a\u6539\u5584\u304c\u898b\u3089\u308c\u307e\u3057\u305f\uff08Brown et al.2014<\/a> ; \u30ab\u30dd\u30c0\u30b0\u30ea\u30aa\u4ed62003<\/a>\uff09\u3002<\/p>\n\n\n\n

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\u4f55\u3067\u30a2\u30eb\u30b3\u30fc\u30eb\u3067\u7b4b\u7d30\u80de\u304c\u7834\u58ca\u3055\u308c\u308b\u306e\u304c\u89e3\u3063\u305f\u304b\uff1f<\/h2>\n\n\n\n

\u7981\u9152\u85ac\u306e\u6210\u5206\u304b\u3089\u767a\u898b\u306b\u81f3\u3063\u305f\u305d\u3046\u306a<\/h4>\n\n\n\n

\u79c1\u304c\u9762\u767d\u3044\u3068\u601d\u3063\u305f\u306e\u306f\u3001\u3053\u306e\u3053\u3068\u304c\u767a\u898b\u3055\u308c\u305f\u7d4c\u7def\u3067\u3059\u3002<\/p>\n\n\n\n

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\u3053\u308c\u306f\u30a2\u30eb\u30b3\u30fc\u30eb\u306e\u5206\u89e3\u3092\u59a8\u3052\u308b\u85ac\u3002<\/p>\n\n\n\n

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\"\"<\/figure><\/div>\t\t\t\t\t
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